Accueil > L’équipe > Pascale Crépieux

Pascale Crépieux

Education
- PhD thesis at the Pasteur Institute of Lille, France, Laboratory of Molecular Oncology (1993).

- Post-doctoral training at McGill University, Montreal, Canada, Laboratory of Molecular Oncology (1994-1997).

- Post-doctoral training at the Pasteur Institute, Lille, France, Laboratory of Cellular Immunology (1997).

- Qualification to supervise Ph.D. theses (HDR) Université de Tours, 1999.

Position
- Chargée de Recherches CNRS since 2002, BIOS group, UMR Physiologie de la Reproduction et des Comportements », Nouzilly.

- Directrice de Recherches CNRS since 2017, BIOS group, UMR Physiologie de la Reproduction et des Comportements », Nouzilly.

- Co-leader of the « Biology and Bioinformatics of signalling systems » (BIOS) group since 2012

Publications 54 publications in international revues, 1 patent, 5 book chapters and 70 meeting reports.

Honours Award of the Foundation Fertilité Stérilité (Fondation de France), Lyon, 2001

Selected grants Ligue contre le Cancer 1999, 2000, 2003 - Région Centre 2005-2006 and 2014-2015, 2016-2018 Département PHASE INRA (2009-2012)

Selected publications

  • Tréfier A., A. Musnier, F. Landomiel, T. Bourquard, T. Boulo, M.A. Ayoub, K. León, G. Bruneau, M. Chevalier, G. Durand, M.C. Blache, A. Inoue, J. Fontaine, C. Gauthier, S. Tesseraud, E. Reiter, A. Poupon and P. Crépieux. (2017). G protein-dependent signalling triggers a β-arrestin-scaffolded p70S6K/ rpS6 module that controls 5’TOP mRNA translation. FASEB Journal, in press
  • Crépieux P., S. Marion, N. Martinat, V. Fafeur, Y. Le Vern, D. Kerboeuf, F. Guillou and E. Reiter. (2001). The ERK-dependent signalling is stage-specifically modulated by FSH, during primary Sertoli cell maturation. Oncogene, 20, 4696- 4709.
  • Lécureuil C., Tesseraud S., Kara E., Martinat N., Sow A., Fontaine I., Gauthier C., Reiter E., Guillou F. and P. Crépieux. (2005). FSH activates p70 ribosomal protein S6 kinase by protein kinase A-mediated dephosphorylation of Thr 421/ Ser 424 in primary Sertoli cells. Mol. Endocrinol. 19, 1812-1820.
  • Kara E., P. Crépieux, C. Gauthier, N. Martinat, V. Picketty, F. Guillou and E. Reiter. (2006). A phosphorylation cluster in the C-terminus of the follicle stimulating hormone receptor (FSH-R) is important for desensitization and internalization, but not for β-arrestin-meditated ERK activation. Mol. Endocrinol., 20, 3014-3026.
  • Musnier A., D. Heitzler, T. Boulo, C. Lécureuil, G. Durand, S. Tesseraud, H. Guillou, A. Poupon, E. Reiter and P. Crépieux. (2009). Developmental regulation of p70 S6 kinase by a G protein-coupled receptor dynamically modelized in primary cells. Cell. Mol. Life Sci., 66, 3487-3503.
  • Dupont J.*, A. Musnier*, J. Decourtye, T. Boulo, C. Lécureuil, H. Guillou, S. Valet, S. Fouchécourt, J.L. Pitetti, S. Nef, E. Reiter and P. Crépieux. (2010). FSH- stimulated PTEN activity accounts for the lack of FSH mitogenic effect in prepubertal rat Sertoli cells. Mol. Cell. Endocrinol., 315, 271-276 . DOI 10.1016/j.mce.2009.09.016. *Equal contribution.
  • Musnier A., Blanchot B., Reiter E. and P. Crépieux. (2010). GPCR signalling to the translation machinery. Cell. Signal., 10.1016/j.cellsig.2009.10.012.
  • Musnier A.*, K. Leon*, J. Morales, E. Reiter, T. Boulo, V. Costache, P. Vourc’h, D. Heitzler, N. Oulhen, A. Poupon, S. Boulben, P. Cormier and P. Crépieux. (2012). mRNA-selective translation by FSH signalling in primary Sertoli cells. Mol. Endocrinol., 26, 669-680. *equal contribution
  • Heitzler D.*, G. Durand*, N. Gallay, A. Rizk, S. Ahn, J. Kim, J.D. Violin, L. Dupuy, C. Gauthier, V. Piketty, P. Crépieux, A. Poupon, F. Clément, F. Fages, R.J. Lefkowitz, E. Reiter. (2012). Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling. Mol. Syst. Biol., 8, 590. *equal contribution
  • León K., T. Boulo, Musnier A., J. Morales, C. Gauthier, L. Dupuy, S Heyne, R. Backofen, A. Poupon, P. Cormier, E. Reiter and P. Crépieux. (2014). FSH-induced signaling leads to rapamycin-sensitive phosphorylation of eIF4G at the 5’cap, and also to IRES-dependent translation. J. Mol. Endocrinol., 52, 373-382.
  • Le Borgne M, K. Buchet-Poyau, N. Chartier, O. Destaing, E. Faurobert, C. Thibert, J.P. Rouault, J. Courchet, D. Nègre, D. Bouvard, C. Albiges-Rizzo, S. Rousseaux, S. Kochbin, D. Segrétain, P. Crépieux, F. Guillou, P. Durand, M.H. Perrard and M. Billaud. (2014). The RNA-binding protein MEX-3B regulates spatial organization of the Rap1 pathway. Development, 141, 2096-107.
  • Bourquard T., F. Landomiel, E. Reiter, P. Crépieux, D. Ritchie, J. Azé and A. Poupon. (2015). Unraveling the molecular architecture of a G protein-coupled receptor/ β-arrestin/ Erk module complex. Sci. Rep., in press.
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